| Name | Group | Language of Origin | Languages of Use | Meaning/Translation or Related Words | US 2021 |
|---|
| Santo | Santo/Sante | Latin | Italian | | |
| Sara | Sarah | Hebrew | German, Scandinavian, Spanish, Italian, Czech, Albanian | princess, noblewoman | #196 |
| Saturno | Saturn | Latin | Portuguese, Spanish, Italian | | |
| Saveria | Xavier/Xaveria | Basque | Italian | Words: house / new | |
| Saverio | Xavier/Xaveria | Basque | Italian | Words: house / new | |
| Saviero | Xavier/Xaveria | Basque | Italian | Words: house / new | |
| Savina | Sabino/Sabine | Latin | Italian | | |
| Savino | Sabino/Sabine | Latin | Italian | | |
| Sebastiana | Sebastian/Sebastina | Old Greek | Italian | from Sebaste | |
| Sebastiano | Sebastian/Sebastina | Old Greek | Italian | from Sebaste | |
| Secondo | Secondo/Segunda | Latin | Italian | | |
| Sefora | Zipporah | Hebrew | Italian | bird | |
| Selenio | Selenio/Selina | Old Greek | Italian | moon | |
| Serafina | Seraphin/Seraphina | Hebrew | Italian | angel | |
| Serafino | Seraphin/Seraphina | Hebrew | Italian | angel | |
| Serena | Serenus/Serena | Latin | German, Italian | peaceful, serene | #386 |
| Serenella | Serenus/Serena | Latin | Italian | peaceful, serene | |
| Sereno | Serenus/Serena | Latin | Italian | peaceful, serene | |
| Sergio | Serge | Etrusk | Portuguese, Spanish, Italian | | #383 |
| Sesto | Sesto | Latin | Italian | Words: sixth | |
| Severiano | Severin/Severina | Latin | Italian | the severe | |
| Severina | Severin/Severina | Latin | German, Italian | the severe | |
| Severino | Severin/Severina | Latin | Italian | the severe | |
| Severo | Severin/Severina | Latin | Italian | the severe | |
| Sibilla | Sibylle | Old Greek | Italian | | |
| Sigfrido | Siegfried | Old High German | Italian | Words: victory / peace, protection, safety | |
| Sigismondo | Siegmund | Old High German | Italian | Words: victory / protection, protector | |
| Silvana | Silvan/Silvana | Latin | German, Italian | Words: wood, forest | |
| Silvano | Silvan/Silvana | Latin | Italian | Words: wood, forest | |
| Silvestro | Silvester | Latin | Italian | of the forest | |
| Silvia | Silvius/Silvia | Latin | German, Italian | forest man | |
| Silviano | Silvan/Silvana | Latin | Spanish, Italian | Words: wood, forest | |
| Silvio | Silvius/Silvia | Latin | Spanish, Italian | forest man | |
| Simeone | Simon/Simone | Hebrew | Italian | He (God) has heard | |
| Simona | Simon/Simone | Hebrew | Scandinavian, Italian | He (God) has heard | |
| Simone | Simon/Simone | Hebrew | Italian | He (God) has heard | |
| Simonetta | Simon/Simone | Hebrew | Italian | He (God) has heard | |
| Siro | Sirius/Siria | Old Greek | Italian | | |
| Sisto | Sixtus/Sixte | Old Greek | Italian | | |
| Smeralda | Esmeralda | Spanish | Italian | smaragd | |
| Socrate | Sokrates | Old Greek | Italian, French | Words: safe / power | |
| Sofia | Sophia | Old Greek | German, Scandinavian, Italian | wisdom | #18 |
| Sofronia | Sophia | Old Greek | Italian | wisdom | |
| Sole | Sole | Italian | Italian | sun | |
| Solidea | Solideo/Solidea | Latin | Italian | only for God | |
| Solideo | Solideo/Solidea | Latin | Italian | only for God | |
| Sophia | Sophia | Old Greek | German, Italian, English, Russian | wisdom | #6 |
| Spartaco | Spartaco | Latin | Italian | from Sparta | |
| Stanislao | Stanislaw/Stanislava | Old Slavic | Italian | Words: strength, firmness / fame, glory, Slav | |
| Stefani | Steven/Stephanie | Old Greek | Italian | the crowned | |
| Stefano | Steven/Stephanie | Old Greek | Italian | the crowned | |
| Stella | Stella | Latin | German, Italian, English | star | #41 |
| Stellario | Stellario | Latin | Italian | | |
| Susana | Susanne | Hebrew | Spanish, Italian | lily | |
| Susanna | Susanne | Hebrew | German, Italian | lily | |
| Susetta | Susanne | Hebrew | Italian | lily | |
| Sylvia | Silvius/Silvia | Latin | German, Italian | forest man | #467 |
| Taddeo | Thaddeus | Aramaic | Italian | | |
| Tàide | Thaïs | Old Greek | Italian | | |
| Tancredi | Dankrad | Old High German | Italian | Words: counsel, advice, advisor | |
| Tarcisio | Tarcisio | Latin | Italian | | |
| Tatiana | Taziano/Tatjana | Latin | Spanish, Portuguese, Italian, English, French | | #993 |
| Taziana | Taziano/Tatjana | Latin | Italian | | |
| Taziano | Taziano/Tatjana | Latin | Italian | | |
| Tazio | Taziano/Tatjana | Latin | Italian | | |
| Tea | Dorotheus/Dorothea | Old Greek | Italian | gift of God | |
| Tecla | Thekla | Old Greek | Italian | Words: God / glory | |
| Teobaldo | Theobald | Old High German | Italian | Words: people / bold, brave | |
| Teodolinda | Dietlinde | Old High German | Italian | Words: people / gentle, friendly / lime, linden, lime-wood shield | |
| Teodora | Theodore/Theodora | Old Greek | Spanish, Italian | gift of god | |
| Teodorico | Theoderich | Gothic | Italian | Words: ruler | |
| Teodoro | Theodore/Theodora | Old Greek | Portuguese, Spanish, Italian | gift of god | |
| Teofilo | Theophil | Old Greek | Portuguese, Spanish, Italian | Words: God / friend | |
| Teresa | Teresio/Theresa | Old Greek | Spanish, Italian | maybe the hunteress | #823 |
| Teresio | Teresio/Theresa | Old Greek | Italian | maybe the hunteress | |
| Terra | Terra | Latin | Portuguese, Italian, English | earth, land | |
| Tiberio | Tiberius | Latin | Italian | Words: river god, Tiber | |
| Timotea | Timotheus/Timotea | Old Greek | Italian | honoring God | |
| Timoteo | Timotheus/Timotea | Old Greek | Spanish, Italian | honoring God | |
| Tina | Tina | German | German, Scandinavian, English, Italian | | |
| Tindara | Tindara | Old Greek | Italian | | |
| Tino | Valentine/Valentina | Latin | Italian | the strong, the healthy | |
| Tito | Titus/Tiziana | Latin | Spanish, Italian | | |
| Tizia | Tizio/Tizia | Latin | German, Italian | | |
| Tiziana | Titus/Tiziana | Latin | German, Italian | | |
| Tiziano | Titus/Tiziana | Latin | Italian | | |
| Tizio | Tizio/Tizia | Latin | Italian | | |
| Tobia | Tobias | Hebrew | Italian | Yahweh is good | |
| Tomaso | Thomas/Thomasina | Aramaic | Italian | twin | |
| Tommaso | Thomas/Thomasina | Aramaic | Italian | twin | |
| Tonia | Anthony/Antonia | Latin | Italian, English | | |
| Torquato | Torquato | Latin | Italian | | |
| Tosca | Tosco/Tosca | Latin | Italian | | |
| Tosco | Tosco/Tosca | Latin | Italian | | |
| Tullio | Tullio/Tullia | Latin | Italian | | |
| Tullo | Tullio/Tullia | Latin | Italian | | |
| Turi | Salvatore/Salvatrice | Latin | Italian | the saviour | |
| Ubalda | Ubaldo/Ubalda | Old High German | Italian | Words: mind, spirit / bold, brave | |
| Ubaldo | Ubaldo/Ubalda | Old High German | Italian | Words: mind, spirit / bold, brave | |
| Uberta | Hubert/Huberta | Old High German | Italian | Words: mind, spirit / bright | |
